Fenclonine
Fenclonine (also known as para-chlorophenylalanine or PCPA) is a synthetic compound that is known for its role in the field of neuroscience and pharmacology. It is a derivative of the essential amino acid phenylalanine, and is primarily used as a research tool in animal and tissue studies.
History[edit | edit source]
Fenclonine was first synthesized in the mid-20th century. Its effects on the serotonin system were discovered in the 1960s, leading to its use as a research tool in the study of this neurotransmitter system.
Mechanism of Action[edit | edit source]
Fenclonine acts as a serotonin antagonist. It inhibits the enzyme tryptophan hydroxylase, which is necessary for the synthesis of serotonin. This results in a decrease in the levels of serotonin in the brain, which can be useful in studies investigating the role of serotonin in various physiological and psychological processes.
Uses[edit | edit source]
Fenclonine is primarily used in research settings. It is often used in animal and tissue studies to investigate the role of serotonin in various processes, such as mood regulation, sleep, and appetite. It has also been used in studies investigating the effects of serotonin depletion on behavior and cognition.
Side Effects[edit | edit source]
As with any pharmacological agent, Fenclonine can have side effects. These can include changes in mood, sleep disturbances, and changes in appetite. However, these side effects are typically mild and temporary.
See Also[edit | edit source]
References[edit | edit source]
- Pharmacology of Serotonin, by R. M. Buijs, D. F. Swaab
- The Biochemical Basis of Neuropharmacology, by Jack R. Cooper, Floyd E. Bloom, Robert H. Roth
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