FinnGen

A large-scale public-private research project in Finland

FinnGen logo

FinnGen is a large-scale public-private research project in Finland that aims to collect and analyze genetic data from 500,000 Finnish participants. The project seeks to improve human health through genetic research by identifying genetic factors associated with diseases and health traits. FinnGen is a collaborative effort involving Finnish universities, hospitals, and international pharmaceutical companies.

Overview

FinnGen was launched in 2017 and is expected to run for six years. The project is funded by both public and private sectors, including the Finnish government and several pharmaceutical companies. The primary goal of FinnGen is to combine genetic data with health records to discover new insights into the genetic basis of diseases.

Objectives

The main objectives of FinnGen include:

• Identifying genetic variants that contribute to common and rare diseases.
• Understanding the genetic architecture of complex traits.
• Developing new diagnostic tools and treatments based on genetic findings.
• Enhancing the understanding of the genetic basis of health and disease in the Finnish population.

Methodology

FinnGen utilizes a biobank approach, where genetic data is collected from participants who have consented to the use of their health records for research purposes. The project leverages the unique genetic makeup of the Finnish population, which is characterized by a relatively homogeneous gene pool due to historical population bottlenecks.

Data Collection

Participants in FinnGen are recruited through Finnish biobanks, and their genetic data is linked to national health registries. This linkage allows researchers to study the relationship between genetic variants and health outcomes over time.

Analysis

The genetic data collected is analyzed using advanced bioinformatics tools to identify associations between genetic variants and diseases. The findings are then validated through replication studies and functional analyses.

Impact

FinnGen has the potential to significantly impact the field of genomics and personalized medicine. By identifying genetic risk factors for diseases, the project can contribute to the development of targeted therapies and preventive strategies. Additionally, the insights gained from FinnGen can inform public health policies and improve healthcare delivery in Finland and beyond.

Ethical Considerations

FinnGen places a strong emphasis on ethical considerations, including informed consent, data privacy, and the responsible use of genetic information. The project adheres to strict ethical guidelines to ensure the protection of participants' rights and the confidentiality of their data.

Related pages

• Genomics
• Biobank
• Personalized medicine
• Genetic epidemiology