Icatibant
(Redirected from Firazyr)
A detailed overview of Icatibant, a medication used in the treatment of hereditary angioedema.
Icatibant[edit | edit source]
Icatibant is a medication used primarily in the treatment of hereditary angioedema (HAE), a rare genetic condition characterized by recurrent episodes of severe swelling. It is a synthetic peptide and functions as a selective bradykinin B2 receptor antagonist.
Mechanism of Action[edit | edit source]
Icatibant works by blocking the bradykinin B2 receptor, which is involved in the inflammatory process that leads to the symptoms of hereditary angioedema. By inhibiting this receptor, icatibant reduces the effects of bradykinin, a peptide that causes blood vessels to dilate and become more permeable, leading to swelling.
Clinical Use[edit | edit source]
Icatibant is administered via subcutaneous injection and is used to treat acute attacks of hereditary angioedema. It is particularly effective in reducing the duration and severity of swelling episodes. Patients are often trained to self-administer the medication at the onset of an attack.
Side Effects[edit | edit source]
Common side effects of icatibant include injection site reactions, such as redness, swelling, and pain. Other potential side effects may include fever, dizziness, and headache. It is generally well-tolerated, but patients should be monitored for any adverse reactions.
Pharmacokinetics[edit | edit source]
Icatibant is rapidly absorbed following subcutaneous administration, with peak plasma concentrations typically reached within 30 to 60 minutes. It has a half-life of approximately 1 to 2 hours, and its effects can last for several hours, providing relief from acute symptoms of hereditary angioedema.
Development and Approval[edit | edit source]
Icatibant was developed as a targeted therapy for hereditary angioedema, addressing the specific pathophysiological mechanism of the disease. It has been approved for use in several countries and is considered a significant advancement in the management of HAE.
Related pages[edit | edit source]
Transform your life with W8MD's budget GLP1 injections from $125
W8MD offers a medical weight loss program NYC and a clinic to lose weight in Philadelphia. Our W8MD's physician supervised medical weight loss centers in NYC provides expert medical guidance, and offers telemedicine options for convenience.
Why choose W8MD?
- Comprehensive care with FDA-approved weight loss medications including:
- loss injections in NYC both generic and brand names:
- weight loss medications including Phentermine, Qsymia, Diethylpropion etc.
- Accept most insurances for visits or discounted self pay cost.
- Generic weight loss injections starting from just $125.00 for the starting dose
- In person weight loss NYC and telemedicine medical weight loss options in New York city available
- Budget GLP1 weight loss injections in NYC starting from $125.00 biweekly with insurance!
Book Your Appointment
Start your NYC weight loss journey today at our NYC medical weight loss, and Philadelphia medical weight loss Call (718)946-5500 for NY and 215 676 2334 for PA
Search WikiMD
Ad.Tired of being Overweight? Try W8MD's NYC physician weight loss.
Semaglutide (Ozempic / Wegovy and Tirzepatide (Mounjaro / Zepbound) available. Call 718 946 5500.
Advertise on WikiMD
WikiMD's Wellness Encyclopedia |
Let Food Be Thy Medicine Medicine Thy Food - Hippocrates |
Translate this page: - East Asian
中文,
日本,
한국어,
South Asian
हिन्दी,
தமிழ்,
తెలుగు,
Urdu,
ಕನ್ನಡ,
Southeast Asian
Indonesian,
Vietnamese,
Thai,
မြန်မာဘာသာ,
বাংলা
European
español,
Deutsch,
français,
Greek,
português do Brasil,
polski,
română,
русский,
Nederlands,
norsk,
svenska,
suomi,
Italian
Middle Eastern & African
عربى,
Turkish,
Persian,
Hebrew,
Afrikaans,
isiZulu,
Kiswahili,
Other
Bulgarian,
Hungarian,
Czech,
Swedish,
മലയാളം,
मराठी,
ਪੰਜਾਬੀ,
ગુજરાતી,
Portuguese,
Ukrainian
Medical Disclaimer: WikiMD is not a substitute for professional medical advice. The information on WikiMD is provided as an information resource only, may be incorrect, outdated or misleading, and is not to be used or relied on for any diagnostic or treatment purposes. Please consult your health care provider before making any healthcare decisions or for guidance about a specific medical condition. WikiMD expressly disclaims responsibility, and shall have no liability, for any damages, loss, injury, or liability whatsoever suffered as a result of your reliance on the information contained in this site. By visiting this site you agree to the foregoing terms and conditions, which may from time to time be changed or supplemented by WikiMD. If you do not agree to the foregoing terms and conditions, you should not enter or use this site. See full disclaimer.
Credits:Most images are courtesy of Wikimedia commons, and templates, categories Wikipedia, licensed under CC BY SA or similar.
Contributors: Prab R. Tumpati, MD