Fluoromedroxyprogesterone acetate

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Fluoromedroxyprogesterone acetate.svg


Fluoromedroxyprogesterone acetate (FMPA, 9α-fluoromedroxyprogesterone acetate, or 9α-FMPA) is a synthetic steroid medication which was under development by Meiji Dairies Corporation in the 1990s and 2000s for the potential treatment of cancers but was never marketed.[1][2][3][4][5][6][7] It is described as an antiangiogenic agent, with about two orders of magnitude greater potency for inhibition of angiogenesis than its parent compound medroxyprogesterone acetate.[2][4][5] FMPA showed about the same affinities for the progesterone and glucocorticoid receptors as MPA.[4] It reached the preclinical phase of research prior to the discontinuation of its development.[1]

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References[edit | edit source]

  1. ↑ 1.0 1.1 https://adisinsight.springer.com/drugs/800011224
  2. ↑ 2.0 2.1
  3. ↑
  4. ↑ 4.0 4.1 4.2
  5. ↑ 5.0 5.1
  6. ↑
  7. ↑

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Contributors: Prab R. Tumpati, MD