Fluralaner

Fluralaner is a systemic insecticide and acaricide that belongs to the isoxazoline class of chemicals. It is used in veterinary medicine to treat and prevent flea and tick infestations in dogs and cats.

Chemistry

Fluralaner is a member of the isoxazoline class of chemicals, which are synthetic compounds. It has a molecular formula of C22H17Cl2F6N3O and a molecular weight of 556.28 g/mol. The chemical structure of fluralaner is characterized by a central isoxazoline ring, which is responsible for its insecticidal and acaricidal activity.

Mechanism of Action

Fluralaner acts on the nervous system of insects and acarids by inhibiting the gamma-aminobutyric acid (GABA)-gated chloride channels and glutamate-gated chloride (GluCl) channels. This results in uncontrolled neural activity, leading to death of the parasites.

Uses

Fluralaner is used in veterinary medicine for the treatment and prevention of flea and tick infestations in dogs and cats. It is administered orally and provides protection against fleas and ticks for up to 12 weeks. It is also effective against the Lone Star tick for 8 weeks.

Safety

Fluralaner is generally well tolerated in dogs and cats. The most common side effects include vomiting, decreased appetite, diarrhea, and lethargy. It should not be used in animals with a known hypersensitivity to fluralaner or any other isoxazoline class compounds.

References

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