Folipastatin
Folipastatin is a lipopeptide antibiotic that is produced by the bacterium Bacillus subtilis. It is known for its ability to inhibit the enzyme phospholipase A2, which plays a crucial role in the inflammatory response and cell membrane maintenance.
Structure and Synthesis[edit | edit source]
Folipastatin is a cyclic lipopeptide, meaning it consists of a lipid portion and a peptide portion that forms a cyclic structure. The lipid portion is a fatty acid chain, while the peptide portion is composed of several amino acids. The synthesis of folipastatin is carried out by nonribosomal peptide synthetases (NRPSs) in Bacillus subtilis.
Mechanism of Action[edit | edit source]
Folipastatin's primary mechanism of action is the inhibition of phospholipase A2. This enzyme is responsible for the hydrolysis of phospholipids, leading to the production of arachidonic acid and lysophospholipids. By inhibiting this enzyme, folipastatin can prevent the production of these molecules, thereby reducing inflammation and maintaining cell membrane integrity.
Medical Applications[edit | edit source]
Due to its anti-inflammatory properties, folipastatin has potential applications in the treatment of various inflammatory diseases, such as rheumatoid arthritis, asthma, and psoriasis. However, more research is needed to fully understand its therapeutic potential and safety profile.
See Also[edit | edit source]
References[edit | edit source]
Navigation: Wellness - Encyclopedia - Health topics - Disease Index - Drugs - World Directory - Gray's Anatomy - Keto diet - Recipes
Search WikiMD
Ad.Tired of being Overweight? Try W8MD's physician weight loss program.
Semaglutide (Ozempic / Wegovy and Tirzepatide (Mounjaro / Zepbound) available.
Advertise on WikiMD
WikiMD is not a substitute for professional medical advice. See full disclaimer.
Credits:Most images are courtesy of Wikimedia commons, and templates Wikipedia, licensed under CC BY SA or similar.
Translate this page: - East Asian
中文,
日本,
한국어,
South Asian
हिन्दी,
தமிழ்,
తెలుగు,
Urdu,
ಕನ್ನಡ,
Southeast Asian
Indonesian,
Vietnamese,
Thai,
မြန်မာဘာသာ,
বাংলা
European
español,
Deutsch,
français,
Greek,
português do Brasil,
polski,
română,
русский,
Nederlands,
norsk,
svenska,
suomi,
Italian
Middle Eastern & African
عربى,
Turkish,
Persian,
Hebrew,
Afrikaans,
isiZulu,
Kiswahili,
Other
Bulgarian,
Hungarian,
Czech,
Swedish,
മലയാളം,
मराठी,
ਪੰਜਾਬੀ,
ગુજરાતી,
Portuguese,
Ukrainian
Contributors: Prab R. Tumpati, MD