Frescolat ML

Frescolat ML

Frescolat ML is a synthetic cooling agent widely used in the pharmaceutical and cosmetic industries. It is known for its ability to provide a long-lasting cooling sensation on the skin without the use of menthol, which can sometimes cause irritation or allergic reactions in sensitive individuals.

Chemical Composition

Frescolat ML is chemically known as Menthyl Lactate. It is an ester of menthol and lactic acid. The chemical formula for Menthyl Lactate is C13H24O3, and it has a molecular weight of 228.33 g/mol.

Mechanism of Action

Frescolat ML works by activating the TRPM8 receptor, a cold and menthol receptor found in the skin. This receptor is responsible for the sensation of cold temperatures. When Frescolat ML binds to TRPM8, it induces a cooling sensation that can last for several hours.

Applications

Frescolat ML is used in a variety of products, including:

• Topical analgesics: It is used to provide a cooling effect that can help relieve pain and discomfort.
• Cosmetics: It is added to lotions, creams, and gels to impart a refreshing sensation.
• Personal care products: It is found in shampoos, conditioners, and body washes to enhance the sensory experience.

Advantages

• Non-irritating: Unlike menthol, Frescolat ML is less likely to cause skin irritation or allergic reactions.
• Long-lasting effect: The cooling sensation provided by Frescolat ML can last longer than that of natural menthol.
• Versatile: It can be used in a wide range of formulations, including water-based and oil-based products.

Safety and Toxicology

Frescolat ML is generally considered safe for use in cosmetic and pharmaceutical products. It has been evaluated for skin irritation and sensitization, and studies have shown it to be non-irritating and non-sensitizing at typical use concentrations.

Also see

• Menthol
• TRPM8 receptor
• Cooling agents in cosmetics
• Topical analgesics