Frizzled-10

Frizzled-10 is a protein that in humans is encoded by the FZD10 gene. It is a member of the Frizzled family of transmembrane receptors, which are involved in the Wnt signaling pathway and other cellular signaling processes.

Structure

Frizzled-10 is a seven-pass transmembrane receptor, meaning it crosses the cell membrane seven times. Like other members of the Frizzled family, it has a large extracellular cysteine-rich domain (CRD) that is involved in binding to Wnt ligands.

Function

Frizzled-10 is involved in the Wnt signaling pathway, which plays a crucial role in cell differentiation, cell proliferation, and cell migration. It can mediate both canonical and non-canonical Wnt signaling, depending on the context and the specific Wnt ligands present.

In addition to its role in Wnt signaling, Frizzled-10 has been implicated in other cellular processes. For example, it has been shown to play a role in neuronal development and axon guidance, and it may also be involved in cancer progression.

Clinical significance

Alterations in the expression of Frizzled-10 have been observed in several types of cancer, including breast cancer, colorectal cancer, and gastric cancer. These findings suggest that Frizzled-10 could potentially serve as a biomarker for these cancers, although further research is needed to confirm this possibility.

See also

• Frizzled
• Wnt signaling pathway
• Transmembrane receptor

References

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