GAB2

Protein GAB2 PDB 2VWF

GAB2

GAB2 is a gene that encodes the GRB2-associated binding protein 2. It plays a crucial role in various cellular processes, including cell growth, differentiation, and survival. The protein encoded by GAB2 is involved in signal transduction pathways and interacts with several other proteins to regulate cell functions.

Function

GAB2 is a scaffolding protein that mediates the activation of various signaling pathways in response to extracellular stimuli. It interacts with receptor tyrosine kinases and adaptor proteins to transmit signals from the cell surface to the nucleus. GAB2 is essential for the regulation of cell proliferation, differentiation, and survival.

Clinical Significance

Mutations in the GAB2 gene have been associated with various diseases, including cancer and neurological disorders. Dysregulation of GAB2 signaling pathways can lead to uncontrolled cell growth and contribute to the development of cancer. In addition, alterations in GAB2 expression have been linked to neurological conditions such as Alzheimer's disease and autism.

Interactions

GAB2 interacts with a variety of proteins involved in signal transduction, including growth factor receptors, kinases, and adaptor molecules. These interactions are essential for the proper functioning of signaling pathways that control cell behavior. GAB2 is a critical component of the PI3K-Akt and MAPK pathways, which are implicated in cell proliferation and survival.