GFRα3

GFRα3 is a protein that in humans is encoded by the GFRA3 gene. It is a member of the GDNF receptor family. It is a glycosylphosphatidylinositol (GPI)-linked cell surface receptor for both GDNF and NTN, and mediates activation of the RET tyrosine kinase receptor.

Function

GFRα3 is a receptor for neurturin (NTN). Together with the GDNF, NTN forms complexes with and mediates the activity of the RET proto-oncogene. GFRα3 is a member of the GDNF receptor family. It is a glycosylphosphatidylinositol (GPI)-linked cell surface receptor for both GDNF and NTN, and mediates activation of the RET tyrosine kinase receptor.

Clinical significance

Alterations in the GFRA3 gene have been associated with Hirschsprung's disease, a genetic disorder that results in an absence of nerve cells in the colon, leading to severe constipation and intestinal obstruction.

See also

• GDNF family receptor alpha
• RET proto-oncogene

External links

• GFRA3 at the National Center for Biotechnology Information

GFRα3 Resources
Need Help Finding a Doctor? Need help finding a doctor or specialist anywhere in the world? Explore our world directory. WikiMD's DocFinder can assist you in locating millions of physicians.	Medical Knowledge Access the latest research - Most recent articles Ongoing trials.

Translate to: East Asian 中文, 日本, 한국어, South Asian हिन्दी, Urdu, বাংলা, తెలుగు, தமிழ், ಕನ್ನಡ,
Southeast Asian Indonesian, Vietnamese, Thai, မြန်မာဘာသာ, European español, Deutsch, français, русский, português do Brasil, Italian, polski