Neurturin
Neurturin (NRTN) is a protein that in humans is encoded by the NRTN gene. It is a member of the GDNF family of ligands (GFLs) and is a potent survival factor for central nervous system (CNS) neurons.
Function[edit | edit source]
Neurturin is a neurotrophic factor which is closely related to both glial cell line-derived neurotrophic factor (GDNF) and artemin. It signals through a multicomponent receptor system, composed of RET and one of four GFR alpha receptors.
Clinical significance[edit | edit source]
Neurturin has been shown to promote the survival of dopaminergic neurons of the substantia nigra, which are lost in Parkinson's disease. As such, it has been investigated as a potential treatment for Parkinson's disease.
References[edit | edit source]
External links[edit | edit source]
- Neurturin at the US National Library of Medicine Medical Subject Headings (MeSH)
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This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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