TNFRSF18

TNFRSF18 also known as Tumor Necrosis Factor Receptor Superfamily Member 18 is a protein that in humans is encoded by the TNFRSF18 gene. It is a member of the tumor necrosis factor receptor superfamily, which is a group of proteins that play a crucial role in controlling cell survival and death.

Function

TNFRSF18 is a receptor for tumor necrosis factor (TNF) superfamily member 18 (TNFSF18), also known as A proliferation-inducing ligand (APRIL). This receptor is expressed on the surface of activated T cells, B cells, and monocytes. When bound to its ligand, TNFRSF18 can stimulate the proliferation of T cells and the production of interleukin-2.

Clinical Significance

Alterations in the function or expression of TNFRSF18 have been associated with various diseases. For example, mutations in the TNFRSF18 gene have been linked to autoimmune diseases such as rheumatoid arthritis and systemic lupus erythematosus. Additionally, overexpression of TNFRSF18 has been observed in certain types of cancer, including breast cancer and colorectal cancer, suggesting a potential role in tumor progression.

Research

Research into TNFRSF18 is ongoing, with studies investigating its role in immune regulation, cancer progression, and potential as a therapeutic target in autoimmune diseases and cancer.

File:TNFRSF18 protein structure.jpg

Structure of the TNFRSF18 protein. Image from Wikimedia Commons.

See Also

• Tumor necrosis factor
• Tumor necrosis factor receptor
• Autoimmune diseases
• Cancer