NF-kB

NF-κB (nuclear factor kappa-light-chain-enhancer of activated B cells) is a protein complex that controls transcription of DNA, cytokine production and cell survival. NF-κB is involved in cellular responses to stimuli such as stress, cytokines, free radicals, ultraviolet irradiation, oxidized LDL, and bacterial or viral antigens.

Function

NF-κB plays a key role in regulating the immune response to infection. Incorrect regulation of NF-κB has been linked to cancer, inflammatory and autoimmune diseases, septic shock, viral infection, and improper immune development. NF-κB has also been implicated in processes of synaptic plasticity and memory.

Structure

The NF-κB protein complex is held in the cytoplasm by an inhibitory protein, IκBα. Various types of stimuli can lead to the degradation of IκBα, allowing NF-κB to enter the nucleus and activate genes.

Role in Disease

Aberrant activation of NF-κB is frequently observed in many cancers and is also involved in inflammatory responses, further linking inflammation and cancer.

See Also

• Inflammation
• Cancer
• Autoimmune diseases
• Septic shock
• Viral infection
• Immune development

References

NF-kB Resources
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