NF-kB
NF-κB (nuclear factor kappa-light-chain-enhancer of activated B cells) is a protein complex that controls transcription of DNA, cytokine production and cell survival. NF-κB is involved in cellular responses to stimuli such as stress, cytokines, free radicals, ultraviolet irradiation, oxidized LDL, and bacterial or viral antigens.
Function[edit | edit source]
NF-κB plays a key role in regulating the immune response to infection. Incorrect regulation of NF-κB has been linked to cancer, inflammatory and autoimmune diseases, septic shock, viral infection, and improper immune development. NF-κB has also been implicated in processes of synaptic plasticity and memory.
Structure[edit | edit source]
The NF-κB protein complex is held in the cytoplasm by an inhibitory protein, IκBα. Various types of stimuli can lead to the degradation of IκBα, allowing NF-κB to enter the nucleus and activate genes.
Role in Disease[edit | edit source]
Aberrant activation of NF-κB is frequently observed in many cancers and is also involved in inflammatory responses, further linking inflammation and cancer.
See Also[edit | edit source]
References[edit | edit source]
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Contributors: Prab R. Tumpati, MD