TNFRSF18
TNFRSF18 also known as Tumor Necrosis Factor Receptor Superfamily Member 18 is a protein that in humans is encoded by the TNFRSF18 gene. It is a member of the tumor necrosis factor receptor superfamily, which is a group of proteins that play a crucial role in controlling cell survival and death.
Function[edit | edit source]
TNFRSF18 is a receptor for tumor necrosis factor (TNF) superfamily member 18 (TNFSF18), also known as A proliferation-inducing ligand (APRIL). This receptor is expressed on the surface of activated T cells, B cells, and monocytes. When bound to its ligand, TNFRSF18 can stimulate the proliferation of T cells and the production of interleukin-2.
Clinical Significance[edit | edit source]
Alterations in the function or expression of TNFRSF18 have been associated with various diseases. For example, mutations in the TNFRSF18 gene have been linked to autoimmune diseases such as rheumatoid arthritis and systemic lupus erythematosus. Additionally, overexpression of TNFRSF18 has been observed in certain types of cancer, including breast cancer and colorectal cancer, suggesting a potential role in tumor progression.
Research[edit | edit source]
Research into TNFRSF18 is ongoing, with studies investigating its role in immune regulation, cancer progression, and potential as a therapeutic target in autoimmune diseases and cancer.
See Also[edit | edit source]
References[edit | edit source]
Navigation: Wellness - Encyclopedia - Health topics - Disease Index - Drugs - World Directory - Gray's Anatomy - Keto diet - Recipes
Search WikiMD
Ad.Tired of being Overweight? Try W8MD's physician weight loss program.
Semaglutide (Ozempic / Wegovy and Tirzepatide (Mounjaro / Zepbound) available.
Advertise on WikiMD
WikiMD is not a substitute for professional medical advice. See full disclaimer.
Credits:Most images are courtesy of Wikimedia commons, and templates Wikipedia, licensed under CC BY SA or similar.
Translate this page: - East Asian
中文,
日本,
한국어,
South Asian
हिन्दी,
தமிழ்,
తెలుగు,
Urdu,
ಕನ್ನಡ,
Southeast Asian
Indonesian,
Vietnamese,
Thai,
မြန်မာဘာသာ,
বাংলা
European
español,
Deutsch,
français,
Greek,
português do Brasil,
polski,
română,
русский,
Nederlands,
norsk,
svenska,
suomi,
Italian
Middle Eastern & African
عربى,
Turkish,
Persian,
Hebrew,
Afrikaans,
isiZulu,
Kiswahili,
Other
Bulgarian,
Hungarian,
Czech,
Swedish,
മലയാളം,
मराठी,
ਪੰਜਾਬੀ,
ગુજરાતી,
Portuguese,
Ukrainian
Contributors: Prab R. Tumpati, MD