TNFRSF18

TNFRSF18
Symbol	TNFRSF18
HGNC ID	11907
Alternative symbols	–
Entrez Gene	8784
OMIM	604501
RefSeq	NM_004195
UniProt	Q9Y5U5
Chromosome	1p36.33
Locus supplementary data	–

TNFRSF18 (Tumor Necrosis Factor Receptor Superfamily Member 18), also known as GITR (Glucocorticoid-Induced TNFR-Related protein), is a protein that in humans is encoded by the TNFRSF18 gene. This gene is part of the tumor necrosis factor receptor superfamily, which plays a crucial role in the regulation of immune responses.

Function[edit]

TNFRSF18 is primarily expressed on the surface of regulatory T cells (Tregs) and activated T lymphocytes. It is involved in the modulation of immune system functions, particularly in the context of autoimmunity and inflammation. The interaction of TNFRSF18 with its ligand, GITRL (Glucocorticoid-Induced TNFR-Related Ligand), can lead to the activation of NF-kB and MAPK pathways, promoting T cell proliferation and survival.

Clinical Significance[edit]

The TNFRSF18-GITRL interaction has been implicated in various autoimmune diseases, such as rheumatoid arthritis, multiple sclerosis, and systemic lupus erythematosus. It is also being studied for its potential role in cancer immunotherapy, as modulating this pathway could enhance anti-tumor immune responses.

Research[edit]

Research on TNFRSF18 is ongoing to better understand its role in immune regulation and its potential as a therapeutic target. Studies are exploring the use of agonistic antibodies to stimulate TNFRSF18, which could enhance the immune system's ability to fight cancer and chronic infections.

References[edit]

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