GLRB

GLRB (Glycine Receptor Beta) is a protein that in humans is encoded by the GLRB gene. This protein is one of several ligand-gated ion channels that are responsible for mediating the effects of the neurotransmitter glycine.

Function

The GLRB protein is a subunit of the glycine receptor, which is a pentameric transmembrane receptor that binds glycine and modulates chloride flow within neurons. This receptor is one of the primary inhibitory neurotransmitter receptors in the central nervous system. The binding of glycine to its receptor increases the chloride conductance and thus produces hyperpolarization (inhibition of neuronal firing).

Clinical significance

Mutations in the GLRB gene have been associated with hyperekplexia, a rare neurological disorder characterized by an exaggerated startle response to unexpected stimuli. This disorder is caused by defects in glycinergic transmission.

See also

• Glycine receptor
• Hyperekplexia

External links

• GeneCards - GLRB