GML-1

GML-1 (also known as Glycosylated Macrophage Migration Inhibitory Factor-1) is a protein that is encoded by the GML gene in humans. It is a member of the Macrophage Migration Inhibitory Factor (MIF) family of proteins, which play a crucial role in the immune system.

Function

GML-1 is a glycoprotein that is involved in the regulation of macrophage function. It inhibits the migration of macrophages, which are a type of white blood cell that engulfs and digests cellular debris, foreign substances, microbes, and cancer cells in a process called phagocytosis. This inhibition of macrophage migration is a critical part of the immune response, as it prevents the spread of infection and inflammation.

Structure

The GML-1 protein is a homotrimer, meaning it is composed of three identical subunits. Each subunit is a single polypeptide chain, and the three chains are held together by disulfide bonds. The protein also contains several glycosylation sites, where sugar molecules are attached to the protein. This glycosylation is thought to play a role in the protein's function.

Clinical significance

Alterations in the GML-1 gene or protein have been associated with several diseases, including rheumatoid arthritis, asthma, and cancer. In particular, overexpression of GML-1 has been observed in certain types of cancer, suggesting that it may play a role in tumor growth and progression.

See also

• Macrophage Migration Inhibitory Factor
• Immune system
• Glycoprotein
• Macrophage