GMP synthase

GMP synthase is an enzyme that catalyzes the conversion of XMP (xanthosine monophosphate) into GMP (guanosine monophosphate). This process is a key step in the purine biosynthesis pathway, which is essential for the production of DNA and RNA in all living organisms.

Etymology

The term "GMP synthase" is derived from the names of the substrates and products involved in the reaction it catalyzes. "GMP" stands for guanosine monophosphate, the product of the reaction, and "synthase" is a general term for enzymes that catalyze the formation of a new compound.

Function

GMP synthase plays a crucial role in the purine biosynthesis pathway, which is responsible for the production of the purine bases adenine and guanine. These bases are essential components of DNA and RNA, and are also involved in various other cellular processes, such as energy transfer and protein synthesis.

The enzyme catalyzes the conversion of XMP (xanthosine monophosphate) into GMP (guanosine monophosphate), using glutamine as a nitrogen source. This reaction is the final step in the de novo synthesis of guanine nucleotides.

Structure

GMP synthase is a complex enzyme composed of two different subunits: a large subunit (GuaA) and a small subunit (GuaB). The large subunit is responsible for the actual synthesis of GMP, while the small subunit catalyzes the hydrolysis of glutamine to provide the nitrogen needed for the reaction.

Clinical significance

Due to its essential role in DNA and RNA synthesis, GMP synthase is a potential target for antimicrobial and anticancer drugs. Inhibitors of the enzyme could potentially disrupt the growth of bacteria or cancer cells by blocking the production of purine nucleotides.

See also

• Purine metabolism
• Nucleotide synthesis

References

GMP synthase Resources
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