GOLGA8A

GOLGA8A, also known as Golgin A8 family member A, is a protein that in humans is encoded by the GOLGA8A gene. The protein encoded by this gene is a member of the golgin subfamily of coiled-coil proteins. The golgins are localized primarily to the Golgi apparatus and play a role in its structure and function.

Function

The Golgi apparatus is a key organelle in the endomembrane system of eukaryotic cells, playing a central role in the modification, sorting, and transport of proteins and lipids. The golgin subfamily of coiled-coil proteins, including GOLGA8A, have been implicated in the maintenance of Golgi structure and in vesicle tethering. Vesicle tethering involves the initial, long range attachment of a transport vesicle to its target membrane, before the interaction of SNARE proteins to drive membrane fusion.

Clinical significance

Alterations in the Golgi apparatus and its associated proteins, such as GOLGA8A, have been observed in a variety of diseases, including neurodegenerative diseases and cancer. However, the specific role of GOLGA8A in these diseases is not yet fully understood and is the subject of ongoing research.

See also

• Golgi apparatus
• Coiled-coil protein
• Vesicle tethering
• SNARE proteins