GPR182
GPR182 is an abbreviation for G Protein-Coupled Receptor 182, a protein that in humans is encoded by the GPR182 gene. This receptor is part of the large G protein-coupled receptor (GPCR) family, which plays a critical role in signal transduction across cell membranes, affecting various physiological processes.
Function[edit | edit source]
GPR182 is a member of the adhesion GPCR subfamily, which is characterized by an extended extracellular region with various domains that facilitate cell adhesion and interaction with the extracellular matrix. The precise physiological function of GPR182 remains largely unknown due to a lack of comprehensive research. However, like other adhesion GPCRs, it is speculated to be involved in cell adhesion, signaling, and possibly in the regulation of immune responses and developmental processes.
Gene and Expression[edit | edit source]
The GPR182 gene is located on chromosome 10 in humans. Its expression pattern is not fully characterized, but it is believed to be expressed in various tissues throughout the body. The regulation of its expression and the factors that modulate its activity are areas of ongoing research.
Clinical Significance[edit | edit source]
The clinical significance of GPR182 is still under investigation. Given its classification within the GPCR family, it may have implications in various diseases, particularly those involving dysregulated cell signaling and immune responses. GPCRs are known targets for a significant portion of drugs, making GPR182 a potential target for therapeutic intervention once its function and involvement in disease processes are better understood.
Research Directions[edit | edit source]
Future research on GPR182 is likely to focus on elucidating its ligand, signaling pathways, and physiological roles. Understanding these aspects could unveil new therapeutic strategies for diseases linked to GPCR dysfunction. Additionally, studies on the expression pattern of GPR182 in health and disease could provide insights into its potential as a biomarker.
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Contributors: Prab R. Tumpati, MD
