GR
GR or Glucocorticoid Receptor is a type of protein that in humans is encoded by the NR3C1 gene. It is a member of the nuclear receptor family of intracellular receptors and functions as a receptor for glucocorticoids such as cortisol (hydrocortisone).
Structure[edit | edit source]
The Glucocorticoid Receptor is a type of protein that is encoded by the NR3C1 gene in humans. It is a member of the nuclear receptor family of intracellular receptors. The receptor is composed of several domains, defined by their function and the sequence of amino acids that compose them.
Function[edit | edit source]
The primary function of the Glucocorticoid Receptor is to act as a receptor for glucocorticoids such as cortisol (hydrocortisone). When the receptor binds to a glucocorticoid, it undergoes a conformational change that allows it to translocate into the nucleus and bind to glucocorticoid response elements (GRE) in the DNA. This binding results in a change in gene transcription, leading to an increase in the synthesis of anti-inflammatory proteins and a decrease in the synthesis of pro-inflammatory proteins.
Clinical significance[edit | edit source]
Mutations in the NR3C1 gene can lead to a variety of conditions, including glucocorticoid resistance, a condition in which the body's cells become less responsive to glucocorticoids. This can lead to a variety of symptoms, including fatigue, weight loss, and muscle weakness.
See also[edit | edit source]
References[edit | edit source]
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