GR

GR or Glucocorticoid Receptor is a type of protein that in humans is encoded by the NR3C1 gene. It is a member of the nuclear receptor family of intracellular receptors and functions as a receptor for glucocorticoids such as cortisol (hydrocortisone).

Structure

The Glucocorticoid Receptor is a type of protein that is encoded by the NR3C1 gene in humans. It is a member of the nuclear receptor family of intracellular receptors. The receptor is composed of several domains, defined by their function and the sequence of amino acids that compose them.

Function

The primary function of the Glucocorticoid Receptor is to act as a receptor for glucocorticoids such as cortisol (hydrocortisone). When the receptor binds to a glucocorticoid, it undergoes a conformational change that allows it to translocate into the nucleus and bind to glucocorticoid response elements (GRE) in the DNA. This binding results in a change in gene transcription, leading to an increase in the synthesis of anti-inflammatory proteins and a decrease in the synthesis of pro-inflammatory proteins.

Clinical significance

Mutations in the NR3C1 gene can lead to a variety of conditions, including glucocorticoid resistance, a condition in which the body's cells become less responsive to glucocorticoids. This can lead to a variety of symptoms, including fatigue, weight loss, and muscle weakness.

See also

• Nuclear receptor
• Glucocorticoid
• Cortisol
• NR3C1

References

GR Resources
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