GREB1L

From WikiMD's Wellness Encyclopedia


Overview[edit | edit source]

GREB1L (Growth Regulation by Estrogen in Breast Cancer 1-Like) is a gene that encodes a protein involved in various biological processes, including development and growth regulation. It is a member of the GREB1 family, which is known for its role in estrogen-responsive pathways, particularly in breast cancer.

Gene and Protein Structure[edit | edit source]

The GREB1L gene is located on chromosome 18 in humans. It consists of multiple exons and introns, which are transcribed and spliced to produce the GREB1L mRNA. The protein encoded by GREB1L is characterized by several domains that are crucial for its function in cellular processes.

Function[edit | edit source]

GREB1L is primarily involved in the regulation of growth and development. It is expressed in various tissues, including the kidney and the inner ear, and plays a significant role in embryonic development. The protein is believed to interact with other molecular pathways to modulate cell proliferation and differentiation.

Role in Development[edit | edit source]

Research has shown that GREB1L is essential for normal kidney development. Mutations in the GREB1L gene have been associated with renal agenesis, a condition where one or both kidneys fail to develop. Additionally, GREB1L is implicated in the development of the inner ear, influencing hearing and balance.

Involvement in Disease[edit | edit source]

Mutations or dysregulation of GREB1L can lead to developmental disorders. Its role in kidney and ear development makes it a critical gene for understanding congenital anomalies in these organs. Furthermore, due to its similarity to GREB1, which is involved in breast cancer, GREB1L may also have implications in cancer biology, although this area requires further research.

Research and Clinical Implications[edit | edit source]

Ongoing research is focused on understanding the precise mechanisms by which GREB1L influences development and its potential role in disease. Genetic studies and animal models are used to elucidate its function and to explore therapeutic targets for conditions associated with GREB1L mutations.

Also see[edit | edit source]

References[edit | edit source]


Template:Gene-3D-structure Template:Developmental-biology

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Contributors: Prab R. Tumpati, MD