GRID1

GRID1 or Glutamate Ionotropic Receptor Delta Type Subunit 1 is a protein that in humans is encoded by the GRID1 gene. It is a member of the glutamate receptor family, which plays an essential role in human neurological functions.

Function

GRID1 is a subunit of glutamate receptors, which are the predominant excitatory neurotransmitter receptors in the mammalian brain. These receptors are activated in a variety of normal neurophysiologic processes. This gene product belongs to the delta family of ionotropic glutamate receptors, which are sensitive to amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA), and to a lesser extent to kainate.

Clinical Significance

Mutations in the GRID1 gene have been associated with several neurological disorders, including schizophrenia and bipolar disorder. Studies have also suggested a potential link between GRID1 and susceptibility to epilepsy and Alzheimer's disease.

Structure

The GRID1 protein is a large, multi-domain protein that forms a tetramer to function as a glutamate receptor. It is composed of an extracellular N-terminal domain, a transmembrane domain, and an intracellular C-terminal domain. The N-terminal domain is responsible for ligand binding, while the transmembrane domain forms the ion channel.

See Also

• Glutamate receptor
• Neurology
• Schizophrenia
• Bipolar disorder
• Epilepsy
• Alzheimer's disease