GRIK3

GRIK3 or Glutamate Ionotropic Receptor Kainate Type Subunit 3 is a protein that in humans is encoded by the GRIK3 gene. It is a member of the kainate family of glutamate receptors, which are composed of four subunits and function as ligand-activated ion channels.

Function

The protein encoded by this gene is a subunit of a kainate glutamate receptor. Glutamate receptors mediate the majority of excitatory neurotransmission in the brain. This receptor may have a role in synaptic plasticity, a process that underlies learning and memory. It is thought to interact with other proteins, like Neto1 and Neto2, to regulate kainate receptor function.

Clinical significance

Alterations in the gene encoding GRIK3 have been associated with bipolar disorder and schizophrenia. It has also been associated with recurrent major depressive disorder.

Structure

The GRIK3 protein is a transmembrane protein, meaning it spans the membrane of the cells in which it is expressed. It is composed of several domains, including an extracellular amino terminal domain, a ligand-binding domain, a transmembrane domain, and an intracellular carboxy terminal domain.

See also

• Glutamate receptor
• Kainate receptor
• Neurotransmission
• Synaptic plasticity

External links

• GeneCards