GTF3A

GTF3A is a gene that encodes a protein in humans. It is also known as General Transcription Factor IIIA. The GTF3A gene is located on the short (p) arm of chromosome 13 at position 12.3.

Function

The GTF3A gene provides instructions for making a protein called transcription factor IIIA. This protein is a transcription factor, which means it attaches (binds) to specific regions of DNA and helps control the activity of certain genes. Specifically, the transcription factor IIIA protein is involved in the initiation of transcription of ribosomal RNA genes by RNA polymerase III.

Clinical significance

Mutations in the GTF3A gene have been associated with a variety of genetic disorders, including cancer. For example, some studies have suggested that overexpression of the GTF3A gene may play a role in the development of certain types of breast cancer.

See also

• Transcription factor
• Gene
• RNA polymerase III
• Chromosome 13

References

This article incorporates text from the United States National Library of Medicine, which is in the public domain.