GW-6471

GW-6471 is a chemical compound that acts as an antagonist of the peroxisome proliferator-activated receptor alpha (PPARα). It is primarily used in scientific research to study the role of PPARα in various physiological and pathological processes.

Chemical Structure and Properties

GW-6471 is a synthetic compound with the chemical formula C29H24N2O3. It is characterized by its ability to bind to the ligand-binding domain of PPARα, thereby inhibiting its activity. The compound is often used in laboratory settings to elucidate the function of PPARα in metabolic pathways.

Mechanism of Action

PPARα is a nuclear receptor that regulates the expression of genes involved in fatty acid metabolism, energy homeostasis, and inflammation. GW-6471 functions as an antagonist by binding to PPARα and preventing its activation by endogenous ligands. This inhibition allows researchers to study the effects of reduced PPARα activity in various biological contexts.

Applications in Research

GW-6471 is utilized in a variety of research applications, including:

• Metabolic Studies: By inhibiting PPARα, GW-6471 helps researchers understand the role of this receptor in lipid metabolism and energy balance.
• Cardiovascular Research: PPARα is implicated in the regulation of cardiovascular function, and GW-6471 is used to explore its potential as a therapeutic target in cardiovascular diseases.
• Inflammation and Immune Response: The compound is also used to investigate the involvement of PPARα in inflammatory processes and immune system regulation.

Safety and Handling

As with many research chemicals, GW-6471 should be handled with care. Appropriate safety measures, including the use of personal protective equipment and proper laboratory protocols, should be followed to minimize exposure and ensure safe handling.

Also see

• Peroxisome proliferator-activated receptor alpha
• Nuclear receptor
• Lipid metabolism
• Cardiovascular disease