G protein-coupled receptors database

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G protein-coupled receptors database

The G protein-coupled receptors database (GPCRdb) is a comprehensive resource for information on G protein-coupled receptors (GPCRs). GPCRs are a large family of cell surface receptors that play a key role in signal transduction and are involved in numerous physiological processes. The database provides detailed information on the structure, function, and pharmacology of GPCRs, facilitating research and drug discovery.

Overview[edit | edit source]

GPCRdb is designed to serve the scientific community by offering a centralized repository of data related to GPCRs. It includes information on receptor sequences, structures, ligands, and signaling pathways. The database is regularly updated to incorporate the latest research findings and technological advancements.

Features[edit | edit source]

GPCRdb offers several key features:

Receptor Information: Detailed data on the amino acid sequences, structural models, and functional annotations of GPCRs.
Ligand Information: Comprehensive information on ligands that interact with GPCRs, including their chemical properties and binding affinities.
Signaling Pathways: Data on the signaling pathways activated by GPCRs, including downstream effectors and physiological outcomes.
Structural Data: High-resolution structural data from X-ray crystallography and cryo-electron microscopy studies.
Pharmacological Data: Information on the pharmacological properties of GPCRs, including agonists, antagonists, and allosteric modulators.

Applications[edit | edit source]

GPCRdb is widely used in various fields of biomedical research, including:

Drug Discovery: Identifying potential drug targets and understanding the mechanisms of drug action.
Structural Biology: Studying the three-dimensional structures of GPCRs to gain insights into their function and interactions.
Systems Biology: Investigating the complex signaling networks mediated by GPCRs.
Pharmacology: Exploring the pharmacological profiles of GPCRs and their ligands.

Access and Usage[edit | edit source]

GPCRdb is freely accessible to the scientific community. Users can search for specific GPCRs, ligands, or signaling pathways using the database's search tools. The data can be downloaded for further analysis, and interactive tools are available for visualizing receptor structures and ligand interactions.