Gabapentinoids

Gabapentinoids are a class of drugs that are used in the treatment of various neurological disorders. They include gabapentin and pregabalin, among others. These drugs are primarily used to treat epilepsy, neuropathic pain, and in some cases, anxiety disorders.

Mechanism of Action

Gabapentinoids work by binding to the α2δ (alpha-2-delta) subunit of voltage-dependent calcium channels in the central nervous system. This reduces calcium influx at nerve terminals and subsequently reduces the release of excitatory neurotransmitters.

Uses

Gabapentinoids are used in the treatment of several medical conditions. These include:

• Epilepsy: Gabapentinoids are used as adjunctive therapy in the treatment of partial seizures.
• Neuropathic pain: These drugs are used to manage neuropathic pain conditions such as postherpetic neuralgia and diabetic neuropathy.
• Anxiety disorders: Some gabapentinoids, like pregabalin, are used in the treatment of generalized anxiety disorder.

Side Effects

Common side effects of gabapentinoids include dizziness, drowsiness, and peripheral edema. More serious side effects can include respiratory depression and dependence.

See Also

• Gabapentin
• Pregabalin
• Epilepsy
• Neuropathic pain
• Anxiety disorders

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