Gabapentinoids
Gabapentinoids are a class of drugs that are used in the treatment of various neurological disorders. They include gabapentin and pregabalin, among others. These drugs are primarily used to treat epilepsy, neuropathic pain, and in some cases, anxiety disorders.
Mechanism of Action[edit | edit source]
Gabapentinoids work by binding to the α2δ (alpha-2-delta) subunit of voltage-dependent calcium channels in the central nervous system. This reduces calcium influx at nerve terminals and subsequently reduces the release of excitatory neurotransmitters.
Uses[edit | edit source]
Gabapentinoids are used in the treatment of several medical conditions. These include:
- Epilepsy: Gabapentinoids are used as adjunctive therapy in the treatment of partial seizures.
- Neuropathic pain: These drugs are used to manage neuropathic pain conditions such as postherpetic neuralgia and diabetic neuropathy.
- Anxiety disorders: Some gabapentinoids, like pregabalin, are used in the treatment of generalized anxiety disorder.
Side Effects[edit | edit source]
Common side effects of gabapentinoids include dizziness, drowsiness, and peripheral edema. More serious side effects can include respiratory depression and dependence.
See Also[edit | edit source]
Gabapentinoids Resources | ||
---|---|---|
|
|
Navigation: Wellness - Encyclopedia - Health topics - Disease Index - Drugs - World Directory - Gray's Anatomy - Keto diet - Recipes
Search WikiMD
Ad.Tired of being Overweight? Try W8MD's physician weight loss program.
Semaglutide (Ozempic / Wegovy and Tirzepatide (Mounjaro / Zepbound) available.
Advertise on WikiMD
WikiMD is not a substitute for professional medical advice. See full disclaimer.
Credits:Most images are courtesy of Wikimedia commons, and templates Wikipedia, licensed under CC BY SA or similar.
Translate this page: - East Asian
中文,
日本,
한국어,
South Asian
हिन्दी,
தமிழ்,
తెలుగు,
Urdu,
ಕನ್ನಡ,
Southeast Asian
Indonesian,
Vietnamese,
Thai,
မြန်မာဘာသာ,
বাংলা
European
español,
Deutsch,
français,
Greek,
português do Brasil,
polski,
română,
русский,
Nederlands,
norsk,
svenska,
suomi,
Italian
Middle Eastern & African
عربى,
Turkish,
Persian,
Hebrew,
Afrikaans,
isiZulu,
Kiswahili,
Other
Bulgarian,
Hungarian,
Czech,
Swedish,
മലയാളം,
मराठी,
ਪੰਜਾਬੀ,
ગુજરાતી,
Portuguese,
Ukrainian
Contributors: Prab R. Tumpati, MD