Galectin-3
Galectin-3 is a protein that in humans is encoded by the LGALS3 gene. Galectin-3 is a member of the beta-galactoside-binding protein family, which plays a role in modulating cell-cell and cell-matrix interactions. This protein is involved in various biological functions, including apoptosis, cell proliferation, cell differentiation, and cell cycle regulation.
Structure[edit | edit source]
Galectin-3 is a monomer in solution, but can polymerize into multivalent complexes on the cell surface or extracellular matrix. The protein is composed of three structural domains: a short non-lectin segment, which is involved in oligomerization; a collagen-like domain, which participates in self-association and receptor clustering; and a carbohydrate recognition domain (CRD), which mediates binding to galactose-containing glycoconjugates.
Function[edit | edit source]
Galectin-3 is involved in various biological functions. It plays a role in inflammation and immune response, by regulating cell growth and proliferation, and by modulating cytokine production. Galectin-3 also participates in cell adhesion, cell migration, and angiogenesis. In addition, it is involved in tumor progression and metastasis, by promoting cell survival, proliferation, and angiogenesis.
Clinical significance[edit | edit source]
Elevated levels of galectin-3 have been associated with various types of cancer, including breast cancer, ovarian cancer, prostate cancer, and colorectal cancer. It has been suggested that galectin-3 may serve as a potential biomarker for cancer diagnosis and prognosis. Moreover, galectin-3 has been implicated in heart failure, fibrosis, and inflammatory diseases, and may serve as a therapeutic target for these conditions.
See also[edit | edit source]
References[edit | edit source]
Search WikiMD
Ad.Tired of being Overweight? Try W8MD's physician weight loss program.
Semaglutide (Ozempic / Wegovy and Tirzepatide (Mounjaro / Zepbound) available.
Advertise on WikiMD
WikiMD's Wellness Encyclopedia |
Let Food Be Thy Medicine Medicine Thy Food - Hippocrates |
Translate this page: - East Asian
中文,
日本,
한국어,
South Asian
हिन्दी,
தமிழ்,
తెలుగు,
Urdu,
ಕನ್ನಡ,
Southeast Asian
Indonesian,
Vietnamese,
Thai,
မြန်မာဘာသာ,
বাংলা
European
español,
Deutsch,
français,
Greek,
português do Brasil,
polski,
română,
русский,
Nederlands,
norsk,
svenska,
suomi,
Italian
Middle Eastern & African
عربى,
Turkish,
Persian,
Hebrew,
Afrikaans,
isiZulu,
Kiswahili,
Other
Bulgarian,
Hungarian,
Czech,
Swedish,
മലയാളം,
मराठी,
ਪੰਜਾਬੀ,
ગુજરાતી,
Portuguese,
Ukrainian
WikiMD is not a substitute for professional medical advice. See full disclaimer.
Credits:Most images are courtesy of Wikimedia commons, and templates Wikipedia, licensed under CC BY SA or similar.
Contributors: Prab R. Tumpati, MD