Gallopamil
Gallopamil is a calcium channel blocker used in the treatment of hypertension and angina pectoris. It is a derivative of verapamil, a phenylalkylamine class calcium channel blocker, and is notable for its selectivity for the heart's calcium channels over those in the vascular smooth muscle.
Pharmacology[edit | edit source]
Gallopamil functions by inhibiting the influx of calcium ions into cardiac and smooth muscle cells during depolarization. This inhibition results in a decrease in peripheral vascular resistance and a reduction in heart rate, ultimately leading to a decrease in blood pressure. Gallopamil is particularly effective in treating conditions such as hypertension and angina pectoris due to its selectivity for the heart's calcium channels.
Clinical Use[edit | edit source]
Gallopamil is primarily used in the treatment of hypertension and angina pectoris. It can also be used in the management of supraventricular tachycardia and in the prevention of migraine headaches. However, like all calcium channel blockers, it should be used with caution in patients with heart failure or significant left ventricular dysfunction.
Side Effects[edit | edit source]
Common side effects of Gallopamil include dizziness, headache, flushing, and edema. Less common side effects can include bradycardia, hypotension, and constipation. As with all medications, patients should be monitored for any adverse reactions while taking Gallopamil.
See Also[edit | edit source]
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