Gamma-hydroxybutyric acid

Gamma-glutamyl transpeptidase (GGT) is an enzyme that is found in many organs throughout the body, with the highest concentrations found in the liver and kidney. It is involved in the metabolism of glutathione, a molecule that protects the body from oxidative stress.

Function

Gamma-glutamyl transpeptidase plays a key role in the gamma-glutamyl cycle, a pathway that is responsible for the synthesis and degradation of glutathione. This cycle is critical for maintaining cellular health, as glutathione is a major antioxidant that protects cells from damage by reactive oxygen species.

Clinical significance

Elevated levels of GGT in the blood can be an indicator of liver disease, such as hepatitis or cirrhosis, or bile duct obstruction. It can also be elevated in cases of alcohol abuse. As such, GGT is often measured as part of a liver function test.

See also

• Glutathione
• Liver function test
• Gamma-glutamyl cycle