Ganglionic eminence
The Ganglionic Eminence refers to a structure in the embryonic brain from which a large portion of the brain's neurons and glial cells originate. It is a transient structure, meaning it is not present in the mature brain. The ganglionic eminence is a critical component of the ventricular system and plays a significant role in the development of the central nervous system.
Structure[edit]
The ganglionic eminence is divided into three main regions: the medial ganglionic eminence (MGE), the lateral ganglionic eminence (LGE), and the caudal ganglionic eminence (CGE). Each of these regions gives rise to different types of neurons and glial cells.
Medial Ganglionic Eminence[edit]
The Medial Ganglionic Eminence (MGE) is the source of most of the brain's inhibitory GABAergic neurons. These neurons play a crucial role in regulating the excitability of the brain's neural circuits.
Lateral Ganglionic Eminence[edit]
The Lateral Ganglionic Eminence (LGE) gives rise to a variety of cell types, including medium spiny neurons of the striatum, as well as several types of interneurons.
Caudal Ganglionic Eminence[edit]
The Caudal Ganglionic Eminence (CGE) produces a diverse array of interneurons, as well as glial cells.
Development[edit]
The ganglionic eminence begins to form during the embryonic period, around the fifth week of gestation. It continues to develop and differentiate until the late fetal period. The development of the ganglionic eminence is regulated by a complex interplay of genetic and environmental factors.
Clinical Significance[edit]
Abnormalities in the development of the ganglionic eminence can lead to a variety of neurological disorders, including schizophrenia, autism, and epilepsy. Understanding the development and function of the ganglionic eminence can therefore provide important insights into these conditions.
See Also[edit]
References[edit]
-
Interneuron-radial glial interactions in the developing cerebral cortex -
Ganglionic eminence in mice at E12.5
Sponsored Health Resource
W8MD Weight Loss, Sleep & MedSpa
Looking for physician-supervised weight loss, semaglutide, tirzepatide, or GLP-1 receptor agonist options? W8MD helps eligible patients in New York City, Brooklyn, New Jersey, Connecticut, Pennsylvania, Delaware, and greater Philadelphia with medical weight loss, sleep medicine, and long-term maintenance support.
GLP-1 specials: Affordable GLP-1 injections NYC and Philadelphia starting from $29.99/week and up for semaglutide with insurance accepted for qualifying visits, and $45/week and up for tirzepatide with insurance accepted for qualifying visits. Self-pay options start from $59.99/week and up for semaglutide and $69.99/week and up for tirzepatide.
Medical weight loss NYC | Affordable GLP-1 injections NYC | Budget GLP-1 weight loss shots Philadelphia | New Jersey medical weight loss | NYC medical weight loss | Philadelphia medical weight loss | Sleep clinic NYC | W8MD's Philadelphia GLP-1 doctor | Weight loss prescriptions NYC
Book a W8MD appointment · View GLP-1 specials
Paid promotional message. Eligibility, pricing, insurance coverage, medication availability, and results vary. Medical evaluation required.
Medical Disclaimer: WikiMD is for informational purposes only and is not a substitute for professional medical advice. Content may be inaccurate or outdated and should not be used for diagnosis or treatment. Always consult your healthcare provider for medical decisions. Verify information with trusted sources such as CDC.gov and NIH.gov. By using this site, you agree that WikiMD is not liable for any outcomes related to its content. See full disclaimer.
Credits:Most images are courtesy of Wikimedia commons, and templates, categories Wikipedia, licensed under CC BY SA or similar.
Translate page: - East Asian
中文,
日本,
한국어,
South Asian
हिन्दी,
தமிழ்,
తెలుగు,
Urdu,
ಕನ್ನಡ,
Southeast Asian
Indonesian,
Vietnamese,
Thai,
မြန်မာဘာသာ,
বাংলা
European
español,
Deutsch,
français,
Greek,
português do Brasil,
polski,
română,
русский,
Nederlands,
norsk,
svenska,
suomi,
Italian
Middle Eastern & African
عربى,
Turkish,
Persian,
Hebrew,
Afrikaans,
isiZulu,
Kiswahili,
Other
Bulgarian,
Hungarian,
Czech,
Swedish,
മലയാളം,
मराठी,
ਪੰਜਾਬੀ,
ગુજરાતી,
Portuguese,
Ukrainian
