Gardner's

Gardner's syndrome is a rare genetic disorder characterized by the presence of multiple polyps in the colon together with tumors outside the colon. The extracolonic tumors may include osteomas of the skull, thyroid cancer, epidermoid cysts, fibromas, and in rare cases, cancer of the small bowel. Other features may include dental abnormalities. Gardner's syndrome is a variant of familial adenomatous polyposis (FAP).

Signs and Symptoms[edit | edit source]

The signs and symptoms of Gardner's syndrome can vary but may include:

Multiple polyps in the colon
Osteomas (bony tumors) especially in the skull
Soft tissue tumors
Dental abnormalities such as extra or missing teeth
Various types of skin and soft tissue tumors

Causes[edit | edit source]

Gardner's syndrome is caused by mutations in the APC gene. This gene provides instructions for making a protein that helps control how often a cell divides, how it attaches to other cells within a tissue, and whether it moves within or away from a tissue.

Diagnosis[edit | edit source]

Diagnosis of Gardner's syndrome can be challenging because the symptoms can be similar to other conditions. A combination of physical examination, medical history, and genetic testing is typically used to confirm a diagnosis.

Treatment[edit | edit source]

Treatment for Gardner's syndrome typically involves surgery to remove the colon. This is done to prevent the development of colon cancer. Other treatments may be used to manage additional symptoms or complications.

References[edit | edit source]

Gardner's Resources
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