Gastric inhibitory polypeptide receptor
Gastric inhibitory polypeptide receptor (also known as GIPR) is a protein that in humans is encoded by the GIPR gene. This receptor is a member of the G protein-coupled receptor superfamily.
Function[edit | edit source]
The GIPR is a receptor for gastric inhibitory polypeptide (GIP), which is a hormone secreted from the duodenum and jejunum immediately following food ingestion. GIP acts on its receptor in the pancreas to stimulate insulin secretion from beta cells.
Clinical significance[edit | edit source]
Alterations in GIP and GIPR function are associated with diabetes mellitus type 2. In particular, decreased GIPR activity is thought to contribute to the impaired insulin response seen in diabetes.
Structure[edit | edit source]
The GIPR is a seven-transmembrane domain receptor, typical of G protein-coupled receptors. The gene encoding GIPR is located on chromosome 19 in humans.
Research[edit | edit source]
Research into the role of GIP and GIPR in diabetes and obesity is ongoing. Some studies suggest that GIPR antagonists could be a potential therapeutic strategy for the treatment of these conditions.
See also[edit | edit source]
References[edit | edit source]
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Contributors: Prab R. Tumpati, MD
