Gd t cells

Gd t cells - a subset of therapeutic autologous t-lymphocytes that express a t-cell receptor (tcr) composed of one gamma chain and one delta chain, with potential immunomodulating and antineoplastic activities. Upon administration of the therapeutic gamma delta t-lymphocytes, these cells secrete interferon-gamma (ifn-g), and exert direct killing of tumor cells. In addition, these cells activate the immune system to exert a cytotoxic t-lymphocyte (ctl) response against tumor cells. Gamma delta t-lymphocytes play a key role in the activation of the immune system and do not require major histocompatibility complex (mhc)-mediated antigen presentation to exert their cytotoxic effect.