Gelofusine

Gelofusine is a colloid solution used in the medical field as a plasma expander. It is a synthetic, gelatin-based solution that is used to increase blood volume in patients who have experienced significant blood loss or are at risk of hypovolemic shock.

Composition

Gelofusine is composed of 4% succinylated gelatin in a balanced electrolyte solution. The gelatin is derived from bovine collagen and is modified to increase its molecular weight, making it suitable for use as a plasma expander. The electrolyte solution contains sodium, chloride, potassium, and calcium ions, which help to maintain the body's normal electrolyte balance.

Mechanism of Action

The primary function of Gelofusine is to increase the volume of the blood plasma, thereby increasing the overall blood volume. This is achieved by the gelatin molecules in the solution, which are too large to pass through the walls of the blood vessels. As a result, they remain in the bloodstream and draw water into the blood vessels from the surrounding tissues, increasing the volume of the blood.

Indications

Gelofusine is used in situations where there is a need to rapidly increase blood volume. This includes conditions such as trauma, surgery, burns, and sepsis, where significant blood loss may occur. It is also used in the treatment of hypovolemic shock, a condition that can result from severe blood loss.

Side Effects

Like all medications, Gelofusine can cause side effects, although not everybody gets them. These can include allergic reactions, changes in blood pressure, changes in heart rate, and changes in blood chemistry. In rare cases, severe allergic reactions can occur.

Contraindications

Gelofusine should not be used in patients with known allergies to gelatin or any of the other ingredients in the solution. It should also be used with caution in patients with severe heart or kidney disease, as these conditions can affect the body's ability to handle the increased blood volume.

See Also

• Colloid solutions
• Plasma expanders
• Hypovolemic shock