GeneCards
GeneCards[edit | edit source]
GeneCards is a comprehensive database of human genes that provides concise genomic, proteomic, transcriptomic, genetic, and functional information on all known and predicted human genes. It is a valuable resource for researchers, clinicians, and students in the field of genomics and bioinformatics.
Overview[edit | edit source]
GeneCards was developed at the Weizmann Institute of Science in Israel. It integrates information from over 150 web sources, including genomic databases, proteomic databases, and disease databases. The database is designed to provide a comprehensive overview of each gene, including its function, expression, and involvement in diseases.
Features[edit | edit source]
GeneCards offers several key features that make it a useful tool for researchers:
- Gene Summaries: Each gene entry includes a summary that provides an overview of the gene's function, its role in the body, and its involvement in diseases.
- Expression Data: Information on where and when genes are expressed in the body.
- Orthologs and Paralogs: Data on gene orthologs and paralogs, which are genes in different species that evolved from a common ancestral gene.
- Variants and Disorders: Information on genetic variants and their association with diseases.
- Pathways: Details on the biological pathways in which the gene is involved.
[edit | edit source]
GeneCards provides a user-friendly search interface that allows users to search for genes using various keywords, such as gene symbols, aliases, or descriptions. The advanced search options enable users to refine their searches based on specific criteria, such as gene location or function.
GIFtS Score[edit | edit source]
The GeneCards Inferred Functionality Score (GIFtS) is a unique feature of GeneCards. It provides a score that reflects the amount of functional information available for a gene. A higher GIFtS score indicates that more functional data is available, which can be useful for prioritizing genes for further study.
Gene Expression[edit | edit source]
GeneCards includes detailed expression data for each gene, showing where and when the gene is expressed in different tissues and under various conditions. This information is crucial for understanding the gene's role in health and disease.
Sample Gene Page[edit | edit source]
A typical gene page in GeneCards includes sections on gene function, expression, pathways, interactions, and disorders. The page is designed to provide a comprehensive overview of the gene, integrating data from multiple sources.
Related Pages[edit | edit source]
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Contributors: Prab R. Tumpati, MD
