Glisoxepide

Glisoxepide is a sulfonylurea antidiabetic drug that is used in the management of type 2 diabetes. It works by increasing the release of insulin from the pancreas, helping to control blood sugar levels.

Mechanism of Action[edit | edit source]

Glisoxepide, like other sulfonylureas, works by closing ATP-sensitive potassium channels in the beta cells of the Islets of Langerhans in the pancreas. This depolarizes the beta cells and opens voltage-gated calcium channels, allowing calcium to enter the cell. The increase in intracellular calcium stimulates the release of insulin.

Side Effects[edit | edit source]

Possible side effects of glisoxepide include hypoglycemia, nausea, vomiting, diarrhea, abdominal pain, and allergic reactions. In rare cases, it can cause liver damage or blood disorders.

Contraindications[edit | edit source]

Glisoxepide should not be used in patients with type 1 diabetes or diabetic ketoacidosis. It is also contraindicated in patients with severe liver disease or kidney disease, and in those who are allergic to sulfonylureas.

Interactions[edit | edit source]

Glisoxepide may interact with other medications, including beta blockers, warfarin, and phenytoin. It may also interact with alcohol, increasing the risk of hypoglycemia.

See Also[edit | edit source]

Glisoxepide Resources
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