Mitiglinide
(Redirected from Glufast)
Mitiglinide is a drug used for the treatment of Type 2 diabetes. It belongs to the class of drugs known as meglitinides, and is marketed under the trade names Glufast, Glufast L, and Glufast M in Japan by Kissei Pharmaceutical Co., Ltd.
Mechanism of Action[edit | edit source]
Mitiglinide works by stimulating the release of insulin from the pancreas. It does this by binding to ATP-sensitive potassium channels on the surface of the pancreatic beta cells. This binding causes the channels to close, leading to depolarization of the cell membrane and subsequent opening of voltage-gated calcium channels. The influx of calcium into the cell triggers the release of insulin.
Pharmacokinetics[edit | edit source]
Mitiglinide is rapidly absorbed and eliminated, making it suitable for mealtime use. It reaches peak plasma concentrations within an hour of oral administration and has a half-life of approximately two hours. The drug is metabolized in the liver, primarily by the cytochrome P450 enzyme CYP2C8, and to a lesser extent by CYP3A4. The metabolites are excreted in the urine and feces.
Side Effects[edit | edit source]
The most common side effects of mitiglinide are hypoglycemia, weight gain, and gastrointestinal disturbances such as diarrhea and nausea. Less common side effects include dizziness, headache, and joint pain.
Contraindications[edit | edit source]
Mitiglinide is contraindicated in patients with Type 1 diabetes or diabetic ketoacidosis. It should be used with caution in patients with liver disease, as it is metabolized in the liver.
Interactions[edit | edit source]
Mitiglinide may interact with other drugs, including other antidiabetic agents, beta-blockers, and calcium channel blockers. It may also interact with drugs that inhibit or induce the cytochrome P450 enzymes CYP2C8 and CYP3A4.
See Also[edit | edit source]
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