Glycobiarsol

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Glycobiarsol is an antiprotozoal agent that was historically used in the treatment of amebiasis, an infection caused by the Entamoeba histolytica parasite. It belongs to the class of arsenical compounds, which are organic compounds containing arsenic.

Mechanism of Action

Glycobiarsol works by inhibiting the growth and replication of the Entamoeba histolytica parasite. The exact mechanism of action is not fully understood, but it is believed to interfere with the parasite's metabolism and DNA synthesis.

Uses

Glycobiarsol was primarily used to treat amebiasis, particularly in cases where other treatments were ineffective or contraindicated. It was administered orally and was known for its efficacy in eradicating the trophozoite form of the parasite.

Side Effects

The use of glycobiarsol was associated with several side effects, primarily due to its arsenic content. Common side effects included gastrointestinal disturbances such as nausea, vomiting, and diarrhea. More severe side effects could include hepatotoxicity and neurotoxicity.

Discontinuation

Due to the potential for severe side effects and the development of safer and more effective treatments, glycobiarsol is no longer commonly used in clinical practice. Modern treatments for amebiasis include metronidazole and tinidazole, which have a better safety profile.

See Also

• Amebiasis
• Antiprotozoal
• Entamoeba histolytica
• Arsenical

External Links

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