Glycoside hydrolase
(Redirected from Glycosidase)
Glycoside Hydrolase[edit | edit source]
Glycoside hydrolases are a diverse group of enzymes that catalyze the hydrolysis of glycosidic bonds in complex sugars. These enzymes play a crucial role in the digestion of carbohydrates, the breakdown of biomass, and various biological processes.
Classification[edit | edit source]
Glycoside hydrolases are classified based on their sequence similarity and structural features. The CAZy (Carbohydrate-Active enZymes) database is a widely used resource for the classification of these enzymes.
Families[edit | edit source]
Glycoside hydrolases are grouped into families based on amino acid sequence similarity. Each family is thought to have evolved from a common ancestor and typically shares a similar mechanism of action.
Clans[edit | edit source]
Families are further grouped into clans, which are based on structural similarities. Clans can contain multiple families that have converged to similar structural solutions.
Mechanism of Action[edit | edit source]
Glycoside hydrolases can operate through different mechanisms, primarily classified as inverting or retaining mechanisms.
Inverting Mechanism[edit | edit source]
In the inverting mechanism, the enzyme uses a single displacement reaction to invert the configuration of the anomeric carbon.
Retaining Mechanism[edit | edit source]
The retaining mechanism involves a double displacement reaction, which retains the configuration of the anomeric carbon.
Assistance Mechanism[edit | edit source]
Some glycoside hydrolases utilize an assistance mechanism, where an additional molecule or group assists in the hydrolysis process.
Biological Functions[edit | edit source]
Glycoside hydrolases are involved in numerous biological processes, including:
- Digestion of dietary carbohydrates.
- Cell wall remodeling in plants and bacteria.
- Glycoconjugate metabolism.
Industrial Applications[edit | edit source]
These enzymes are used in various industrial applications, such as:
- Biofuel production from lignocellulosic biomass.
- Food industry for the modification of starches and sugars.
- Pharmaceutical industry for drug development.
Related Pages[edit | edit source]
See Also[edit | edit source]
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Contributors: Prab R. Tumpati, MD
