GnRH antagonist

GnRH antagonist

A Gonadotropin-releasing hormone antagonist (often abbreviated as GnRH antagonist) is a type of medication which antagonizes the GnRH receptor and subsequently suppresses the production and release of gonadotropins (LH and FSH) from the anterior pituitary gland.

Mechanism of action

GnRH antagonists compete with GnRH for binding to GnRH receptors, thus reducing the release of luteinizing hormone (LH) and follicle-stimulating hormone (FSH) from the anterior pituitary. This results in a rapid and reversible suppression of gonadotropin secretion, which leads to a decrease in testosterone and estradiol levels.

Uses

GnRH antagonists are used in the treatment of prostate cancer, breast cancer, endometriosis, uterine fibroids, and for assisted reproduction in women. They are also used in the treatment of precocious puberty in children.

Side effects

Common side effects of GnRH antagonists include hot flashes, headache, nausea, and vaginal dryness in women. In men, side effects may include hot flashes, fatigue, and impotence.

See also

• Gonadotropin-releasing hormone agonist
• Gonadotropin-releasing hormone modulator
• Gonadotropin-releasing hormone (GnRH)

References

GnRH antagonist Resources
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