GnRHa

Gonadotropin-releasing hormone agonists (GnRHa) are a group of drugs that are used to control the production of certain hormones in the body. They are often used in the treatment of conditions such as endometriosis, prostate cancer, and uterine fibroids.

Mechanism of Action

GnRHa work by binding to gonadotropin-releasing hormone (GnRH) receptors in the pituitary gland. This causes the pituitary to release luteinizing hormone (LH) and follicle-stimulating hormone (FSH), which in turn stimulate the ovaries or testes to produce estrogen or testosterone, respectively. However, the continuous stimulation of the pituitary by GnRHa eventually leads to a decrease in LH and FSH production, resulting in a decrease in estrogen or testosterone levels.

Uses

GnRHa are used in the treatment of a variety of conditions, including:

• Endometriosis: GnRHa can help to reduce the size of endometrial implants and decrease pain symptoms.
• Prostate cancer: GnRHa are often used to reduce testosterone levels, as testosterone can stimulate the growth of prostate cancer cells.
• Uterine fibroids: GnRHa can help to shrink fibroids and reduce symptoms such as heavy menstrual bleeding and pelvic pain.
• Precocious puberty: GnRHa can be used to delay the onset of puberty in children who are developing too early.

Side Effects

Like all medications, GnRHa can cause side effects. These may include:

• Hot flashes
• Vaginal dryness
• Decreased libido
• Mood changes
• Bone loss

Patients should discuss the potential risks and benefits of GnRHa therapy with their healthcare provider.

See Also

• Gonadotropin-releasing hormone
• Endometriosis
• Prostate cancer
• Uterine fibroids
• Precocious puberty

GnRHa Resources
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