Granulation

Granulation is a key process in the healing of a wound. It involves the formation of new connective tissue and tiny blood vessels that form on the surfaces of a wound during the healing process. Granulation tissue typically appears during the proliferative phase of healing.

Overview

Granulation tissue is new connective tissue and microscopic blood vessels that form on the surfaces of a wound during the healing process. Granulation tissue typically appears during the proliferative phase of healing. Excess granulation tissue is a common problem in wound care, and its treatment can be challenging. The tissue itself is often described as "proud flesh".

Formation

The formation of granulation tissue is often the first sign that a wound is healing. During this process, fibroblasts migrate to the site of the injury, where they begin to produce collagen and other extracellular matrix proteins. This new tissue is highly vascularized and appears red or pink because of the many new blood vessels that are formed.

Role in Wound Healing

Granulation tissue plays a crucial role in the wound healing process. It provides the framework for the growth of new skin, known as epithelialization. The tissue also helps to prevent infection by serving as a barrier against bacteria and other pathogens.

Clinical Significance

In some cases, granulation tissue can overgrow, leading to the formation of granuloma. This can occur in response to foreign bodies, certain types of infections, or long-standing wounds. Overgrowth of granulation tissue can also occur in certain diseases, such as pyogenic granuloma.

Treatment

Treatment of excess granulation tissue may involve the use of topical corticosteroids, silver nitrate, or surgical removal. The choice of treatment depends on the size and location of the granulation tissue, as well as the overall health of the patient.

See Also

• Wound healing
• Granuloma
• Pyogenic granuloma

Granulation Resources
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