Growth-hormone-releasing hormone receptor

Growth-hormone-releasing hormone receptor (GHRHR) is a protein that in humans is encoded by the GHRHR gene. This receptor is a member of the G-protein coupled receptor family and plays a crucial role in the regulation of growth hormone production and release.

Function

The GHRHR is located on the cell membrane of somatotroph cells in the anterior pituitary gland. It binds to growth hormone-releasing hormone (GHRH), triggering a series of intracellular events that lead to the production and release of growth hormone. This process is essential for normal growth and development, particularly during childhood and adolescence.

Structure

The GHRHR is a typical G-protein coupled receptor, consisting of seven transmembrane domains connected by intra- and extracellular loops. The extracellular domain is responsible for binding to GHRH, while the intracellular domain interacts with G-proteins to initiate signal transduction.

Clinical significance

Mutations in the GHRHR gene can lead to isolated growth hormone deficiency (IGHD), a condition characterized by short stature and delayed growth. IGHD can be treated with synthetic growth hormone, but early diagnosis is crucial to prevent long-term complications.

See also

• Growth hormone
• Growth hormone-releasing hormone
• G-protein coupled receptor
• Isolated growth hormone deficiency

References

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