Gsk3b interacting protein

Gsk3b Interacting Protein (also known as GSKIP) is a protein that in humans is encoded by the GSKIP gene. GSKIP is known to interact with Glycogen synthase kinase 3 beta (GSK3B), a protein kinase involved in various cellular processes such as glycogen metabolism, cell cycle, and cell differentiation.

Function

GSKIP is an A-kinase anchoring protein (AKAP) that binds to the regulatory subunit of Protein kinase A (PKA) and confines the holoenzyme to discrete locations within the cell. This protein is involved in the regulation of Glycogen synthase activity by GSK3B and plays a role in Wnt signaling pathway.

Structure

The GSKIP protein is composed of 153 amino acids and has a molecular weight of approximately 17.3 kDa. It contains a PKA-binding domain and a GSK3B-binding domain, which are necessary for its function as an AKAP.

Clinical Significance

Alterations in the GSKIP-GSK3B interaction have been implicated in several diseases, including Parkinson's disease, Alzheimer's disease, and cancer. In particular, GSKIP has been found to be overexpressed in certain types of cancer, suggesting a potential role in tumorigenesis.

Research

Research on GSKIP is ongoing, with studies focusing on its role in disease progression and potential as a therapeutic target. Further understanding of the GSKIP-GSK3B interaction may provide insights into the development of novel treatments for diseases associated with dysregulated GSK3B activity.

File:Gsk3b Interacting Protein.png

Structure of the GSK3B-GSKIP complex. Image from Wikimedia Commons.

See Also

• Glycogen synthase kinase 3
• Protein kinase A
• A-kinase anchoring protein
• Wnt signaling pathway