HBD

Hemoglobin subunit beta (HBD) is a protein that in humans is encoded by the HBD gene. It is a subunit of hemoglobin, the molecule responsible for transporting oxygen in the blood.

Function

HBD is one of the two types of beta globin chains in humans. The other type is hemoglobin subunit delta (HBD). These two types of chains combine with hemoglobin subunit alpha (HBA) to form the complete hemoglobin molecule. Each molecule of hemoglobin contains two alpha and two beta chains.

Clinical significance

Mutations in the HBD gene can cause various forms of beta thalassemia, a group of genetic disorders that result in reduced or absent synthesis of the beta chains of hemoglobin. This can lead to a variety of health problems, including anemia, jaundice, and an enlarged spleen.

See also

• Hemoglobin
• Beta thalassemia
• Hemoglobinopathy

External links

• HBD gene at National Center for Biotechnology Information

HBD Resources
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