HDAC10

HDAC10 or Histone Deacetylase 10 is a protein that in humans is encoded by the HDAC10 gene. It is part of the histone deacetylase family, which plays a key role in the regulation of eukaryotic gene expression.

Function

HDAC10, like other members of the histone deacetylase family, is involved in the deacetylation of lysine residues on the nucleosome core histones, which is an important factor in the regulation of transcription. Deacetylation of histones is associated with transcriptional repression and, in general, histone deacetylases (including HDAC10) are associated with transcription co-repressors.

Structure

The HDAC10 protein has a structure that is similar to other members of the histone deacetylase family. It contains a catalytic domain at its C-terminus and a nuclear localization signal at its N-terminus. The catalytic domain is responsible for the deacetylase activity of the protein, while the nuclear localization signal directs the protein to the nucleus where it can interact with histones and other proteins.

Clinical significance

Alterations in the function of HDAC10 have been associated with several types of cancer, including lung cancer, breast cancer, and leukemia. In these cases, the activity of HDAC10 is often upregulated, leading to increased deacetylation of histones and repression of tumor suppressor genes. Inhibitors of HDAC10 are currently being investigated as potential treatments for cancer.

File:HDAC10.png

Structure of HDAC10

See also

• Histone deacetylase
• Gene expression
• Transcription (genetics)