HLA-A10

HLA-A10 is a human leukocyte antigen (HLA) serotype. The HLA system is a group of genes that encode for proteins on the surface of cells that are responsible for regulation of the immune system in humans. HLA-A10 is part of the HLA-A gene locus, a member of the HLA-A serotype group.

Function

HLA-A10, like other HLAs, plays a crucial role in the immune system's defense against pathogens. It presents peptides (small proteins) derived from inside the cell to the immune system. If these peptides are from a virus or other pathogen, the immune system can then mount a response to destroy the infected cells.

Genetics

The HLA-A10 serotype is encoded by the HLA-A*10 allele group, which is part of the larger HLA-A gene locus on chromosome 6. This locus is highly polymorphic, meaning it has a high degree of genetic variation. This variation is beneficial as it allows the immune system to recognize a wide range of pathogens.

Clinical significance

HLA-A10 has been implicated in a number of diseases. For example, certain HLA-A10 alleles have been associated with increased susceptibility to rheumatoid arthritis and other autoimmune diseases. Additionally, HLA-A10 mismatching can cause problems in organ transplantation, as the immune system may recognize the transplanted organ as foreign and attack it.

See also

• Human leukocyte antigen
• HLA-A
• Immune system
• Autoimmune disease
• Organ transplantation