HLA-A24

HLA-A24 is a human leukocyte antigen serotype within the HLA-A serotype group. The serotype is determined by the antibody recognition of antigen A*24. This broad antigen group also includes the more specific HLA A*2402 and A*2403 serotypes. HLA-A24 is associated with several medical conditions, including cancer, autoimmune diseases, and infectious diseases.

Structure and Function

HLA-A24 is a part of the Major Histocompatibility Complex (MHC) class I molecules, which are expressed in almost all nucleated cells. The primary function of these molecules is to display peptide fragments of non-self-proteins from within the cell to T cells and natural killer cells. This process is crucial for the immune system to recognize infected or cancerous cells.

Medical Significance

HLA-A24 has been associated with various diseases. For instance, it has been linked to an increased risk of hepatitis C infection and progression to liver cirrhosis. It is also associated with a higher risk of type 1 diabetes and certain types of cancer, such as nasopharyngeal carcinoma and gastric cancer.

Research and Therapeutic Applications

Research into HLA-A24 has potential implications for the development of new therapeutic strategies. For example, in cancer immunotherapy, identifying the specific HLA-A24 restricted tumor-associated antigens can help in the design of more effective vaccines.

See Also

• HLA-A
• Major Histocompatibility Complex
• Human leukocyte antigen

References

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