HLA-A28

HLA-A28 is a human leukocyte antigen serotype within the HLA-A serotype group. The serotype is determined by the antibody recognition of antigen A*28. This broad antigen group also includes the more specific serotypes HLA-A*2801, HLA-A*2802, and HLA-A*2803.

Function

HLA-A28, like other HLA-A antigens, plays a crucial role in the immune system. It is involved in the presentation of peptides (small proteins) from inside the cell to T cells, a type of white blood cell that kills cells that are infected with viruses or have become cancerous.

Genetics

HLA-A28 is encoded by the HLA-A gene, which is located on the short arm of chromosome 6 (6p21.3). The HLA-A gene is part of the major histocompatibility complex (MHC), a gene family that is important in immune response.

Clinical significance

HLA-A28 has been associated with various diseases, including autoimmune diseases, infectious diseases, and cancer. For example, it has been linked to an increased risk of rheumatoid arthritis and type 1 diabetes.

See also

• HLA-A
• Human leukocyte antigen
• Major histocompatibility complex
• Autoimmune diseases
• Infectious diseases
• Cancer

References

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